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How ADHD medication works
In ADHD, the brain region prefrontal cortex (responsible for planning, focus, and impulse control) and their networks with the striatum and basal ganglia don’t regulate dopamine and norepinephrine efficiently.
- This leads to inconsistent attention, difficulty sustaining focus, impulsivity, and problems with motivation.
- Mechanism:
- Increase dopamine and norepinephrine levels in synapses.
- Block reuptake transporters (so neurotransmitters stay active longer).
- Amphetamines also increase release of dopamine and norepinephrine from neurons.
- Effect:
- Boosts signal strength in the prefrontal cortex, leads better sustained attention, working memory, and self-regulation.
- Reduces “background noise” in the brain so relevant information is easier to focus on.
How ADHD medication works: click here for more details
Mechanism of action of long acting Vyvanse
Studies on Safety of Vyvanse medication:
ADHD Medication explained
Clinical Studies on effectiveness of long acting stimulant medication for ADHD
These medicines are called stimulants because they increase the brain
chemicals dopamine and norepinephrine.
They are a central nervous system stimulant prescription medicine.
These medications are Schedule 8 medicines which are subject to strict legislative controls due to their high potential for misuse, abuse and dependence.
They come in 2 forms; long acting & short acting
Long acting
Takes from 45-90 mins to work
Lasts from 8-12 hours
One a day
Doses from 20mg to 70mg
This medication is Vyvanse
Vyvanse Patient Information
Vyvanse Clinical Information
Detailed medication data can be found here
Covered on PBS $31.60 for 30 days
Short acting
Takes around 30 mins to work
Lasts from 3-4 hours
Multiple doses per day, upto a max of 8 tablets per day
5mg dose
This medication is Dexamphetamine
Clinical trials highlighting effectiveness and safety
Long-lasting medicines are usually the most practical option because people with ADHD may have trouble remembering to take their medicine.
They also provide steady symptom relief throughout the day. By contrast, if you use short-acting stimulants, your symptoms may return between doses. Some people “crash” as their short-acting dose wears off, meaning their energy and mood drop.
